Can Colgate + YOU be used daily? March 25, 2022 18:36 Updated Yes, Colgate YOU is formulated to be used at least twice daily and is enamel safe. Related articles Is this available as a gel and a paste? Does Colgate + YOU contain sugar? How long will it take to get the toothpaste that I signed up for? What flavors are available? What are the flavors like? What if I am unhappy with the toothpaste? Comments 0 comments Please sign in to leave a comment.